Case Study: The Genetics of Resistance to HIV Infection

Describe the Mutation
Thirty-two base pairs are missing in the CCR5 allele from the EU men, so it is called CCR5Δ32. The nucleotides of both the wildtype and the Δ32 allele are grouped here to show the open reading frame (ORF). How does the 32 base pair deletion affect the ORF?

INSTRUCTIONS:
Choose one of the explanations of how the deletion affects the ORF.

Deletion in Mutated sequence


Which statement describes the effect of the Δ32 mutation?:
arrow Causes a frameshift

arrow Deletes 10 amino acids without changing the reading frame