Case Study: The Genetics of Resistance to HIV Infection

Conclusion
When the cause of AIDS was first discovered in the early 1980s, it seemed that everyone was vulnerable. In this case study we’ve seen that infection by HIV is not a uniform trait in the population. Most people are infectable and no one is absolutely resistant; yet, some people show relative resistance to infection. The two mechanisms we’ve seen here, an effective anti-HIV immune response and a lack of the HIV CCR5 co-receptor, provide insights for research on treatments and vaccines. Perhaps we can’t develop a complete cure for HIV; however, treatments that allow a person to live with HIV are available and continue to improve, based on discoveries like these.

 

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Sources of information used in this case study are listed below.

Berger et al. (1999)Chemokine receptors as HIV co-receptors. Ann Rev Immuno 17:657-700.

Kaul, R. (2001) Late seroconversion in HIV-resistant Nairobi prostitutes despite pre-existing HIV-specific CD8+ responses. J Clin Invest 107: 341-349

Liu, R. et al (1996) Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection Cell 86:367-377 (Aug 9)

Michael, NL (1999) Host genetic influences on HIV-1 pathogenesis Curr Opin Immuno 11:466-474

Paxton, WA et al. (1996) Relative resistance to HIV-1 infection of CD4 lymphocytes from persons who remain uninfected despite multiple high-risk sexual exposures. Nat Med 2(4): 412-417.

Raport, CJ et al. (1996) Molecular cloning and functional characterization of a novel human CC chemokine receptor (CCR5) for RANTES, MIP-1ß, MIP1a. J Biol Chem 271(29): 17161-17166

Stephens, JC et al. (1998) Dating the origin of the CCR5-D32 AIDS-resistance allele by the coalescence of haplotypes. Am J Hum Genet 62:1507-1515.

Martinson JJ, Chapman NH, Rees DC, Liu YT, Clegg JB. (1997). Global distribution of the CCR5 gene 32-basepair deletion. Nat Genet.16(1):100-103.