Case Study: The Genetics of Resistance to HIV Infection

CCR5 Genotype Test
Here are the results of testing the CCR5 gene in three individuals: an EU man, one of his parents, and a control individual (not necessarily in that order).

Use the results to determine each person’s genotype. Then determine which one is EU.

INSTRUCTIONS:
First, determine the correct genotype for the individuals.

Then select which individual is EU.

Graphic: Genotype Test Results


Selected Answer: Individual 1

Incorrect.

The wildtype allele, which encodes a CCR5 protein to which HIV can bind, is larger than the Δ32 allele. The EU individual will have two, small Δ32 alleles.

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