Case Study: The Genetics of Resistance to HIV Infection

Co-Receptors and EU Cells
Both M-tropic and T-tropic HIV-1 strains infect cells using the CD4 receptor, but M-tropic isolates use CCR5 as a co-receptor and T-tropic use CXCR4. This is the key to what’s different about the EU men.

When cells from EU2 and EU3 were mixed with different HIV-1 isolates, the cells were infected by the T-tropic HIV-1 isolates, but not by the M-tropic isolates. What does this suggest about the EU cells?

INSTRUCTIONS:
Select the statement supported by the results of the infection experiment.

Graphic: HIV Infection


Select a Statement:
arrow CD4 is missing or defective

arrow CXCR4 is missing or defective

arrow CCR5 is missing or defective