Unit 6.5 History: Nobel Laureate
Linus Pauling
Prof. Linus Pauling received the Nobel Prize for Chemistry in 1954, for his work on the nature of chemical bonds and the structure of molecules and crystals. He also received the Nobel Peace Prize in 1962. Video program cues: 33:10-35:50

About Prof. Linus Pauling

Links

• The Nobel Prize in Chemistry. Click on links to see Pauling biography and his Nobel acceptance speech.
• Nobel Prize information about Pauling with links to other sources about him.

Readings
Davenport, D.A., (1996)' reviews: The Many Lives of Linus Pauling: A Review of Reviews, 'Journal of Chemical Education, Vol. 73, No. 9, pp: A210.

The discovery of protein folding

"I built so many models by 1948, that I could start to do it in my head, or just on a sheet of paper. What’s wrong about this plane, in the structure I put here [protein structure] is that the angle between these two bonds is 180⁰. But it ought to be 109.47⁰, the Tetrahedral Angle…I don’t think I got any smarter by 1948 than I was in 1937, I didn’t know anything new, but I said suppose that all of these residues are equivalent to one another. I knew then, that the structure that they would have had to assume would have been that of a helix."

Professor Linus Pauling
Nobel Laureate

Link

• A web exhibit devoted to Pauling and his work.

Reading
Bowen, R., Hartung, R., Gindt, Y. M. (2000)' A Simple Protein Purification and Folding Experiment for General Chemistry Laboratory, 'Journal of Chemical Education, Vol. 77, No. 11, pp: 1456-1457.

Proceed to Unit 6.6