Teacher resources and professional development across the curriculum

Teacher professional development and classroom resources across the curriculum

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Sub Image2:Macro to Micro Structures
1) Atoms and Molecules2) Macro to Micro Structures 3) Energetics and Dynamics 4) Theory and Practice in Chemical Systems 5) Chemical Design
6) The Chemistry of Life7) Chemistry and the Environment8) Chemistry at the Interface

Unit 5.5 Designing Molecules
Students discover through literature searches, lab work, and oral presentations how everyday materials, like aspirin, are designed and made.
Video program cues: 31:55 — 44:05

Chemistry personal topic

Lisa Morine teaches her students about chemical research and design.



Scaling up processes

"We are working with very small quantities of compounds so we can put it into biological assay, and find the molecule that we eventually want to use as our drug. Once we have identified this molecule, we need to think about how to produce it in large quantities, on a kilogram scale. Typically, here we produce between 1-20 milligrams of our compound. We then want to go to the factory scale and produce it on a 20-ton scale or kilo scale, which requires us to really focus on our synthesis and make our synthesis as elegant as possible. You want the fewest number of steps, you want it to be economically feasible, and you want it to be environmentally friendly. And that really causes one to focus on the chemistry in order to scale it to the kilos."

Dr. Michael Robbins
Research Chemist, MERCK & Co.

Kenkel, J., Hemmerling, B., Kelter, P.B. (1999)' Innovations for an Industry-Based Curriculum: The I.O.N.S. Concept, 'Journal of Chemical Education, Vol. 76, No. 7, pp: 889-891.

Proceed to Unit 5.6 arrow

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