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Unit 5.5 Designing Molecules
Students discover through literature searches, lab work,
and oral presentations how everyday materials, like aspirin,
are designed and made.
Video program cues: 31:55 — 44:05
Chemistry personal topic
Lisa Morine teaches her students about chemical research
and design.
Activity
Link
Scaling up processes
"We are working with very small quantities
of compounds so we can put it into biological assay, and
find the molecule that we eventually want to use as our
drug. Once we have identified this molecule, we need to
think about how to produce it in large quantities, on a
kilogram scale. Typically, here we produce between 1-20
milligrams of our compound. We then want to go to the factory
scale and produce it on a 20-ton scale or kilo scale, which
requires us to really focus on our synthesis and make our
synthesis as elegant as possible. You want the fewest number
of steps, you want it to be economically feasible, and you
want it to be environmentally friendly. And that really
causes one to focus on the chemistry in order to scale it
to the kilos."
Dr. Michael Robbins
Research Chemist, MERCK & Co.
Reading
Kenkel, J., Hemmerling, B., Kelter, P.B. (1999)' Innovations
for an Industry-Based Curriculum: The I.O.N.S. Concept,
'Journal of Chemical Education, Vol. 76, No. 7, pp:
889-891.
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to Unit 5.6 |
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