Teacher resources and professional development across the curriculum

Teacher professional development and classroom resources across the curriculum

Monthly Update sign up
Mailing List signup
Search
Rediscovering Biology Logo
Home
Online TextbookCase StudiesExpertsArchiveGlossarySearch
Unit 2: Proteins and Proteomics
Back to Unit Page
Unit Content
Unit Textbook Chapter
Animations & Images
Expert Interview Transcripts
Unit Glossary
Related Resources
View Text Only List
Animations

Mass SpectrometerMass Spectrometer
A depiction of what happens inside a mass spectrometer.
View Quicktime Movie
The Evolution of Protein-Protein InteractionsThe Evolution of Protein-Protein Interactions
A depiction of how evolution can affect how proteins interact with other proteins.
View Quicktime Movie
The Three-Dimensional Structure of a ProteinThe Three-Dimensional Structure of a Protein
A depiction of the subsets of a protein structure.
View Quicktime Movie
Virtual Ligand Screening in Drug DesignVirtual Ligand Screening in Drug Design
Shows how a computer program can be used to fit potential drug molecules into a site of interest on a protein.
View Quicktime Movie


Images

2D gel of proteins2D gel of proteins
Haemophilus influenzae cell proteins separated by 2D gel electrophoresis. The basic proteins are to the right of the gel and the acidic proteins to the left. High molecular weight proteins are to the top of the gel.
Active site Active site
The active site of the penicillin-binding protein. The gray stick-like structures represent the secondary and tertiary structure of the penicillin-binding protein. Binding of the antibiotic, the substrate, to the active site blocks the normal action of the protein in the bacterial cell, resulting in death of the cell.
Alternative splicingAlternative splicing
More than one protein can be made from a gene. In this case, three different mRNA molecules are made from one gene. The exons (the numbered boxes) can combine in different configurations to eventually form different proteins.
Drug binding to active site of proteinDrug binding to active site of protein
In virtual ligand screening, the three-dimensional image of the protein is fed into a computer, which attempts to fit millions of small molecules to a targeted active site. Small molecules that bind well to the protein become good leads for potential new drugs.
John KendrewJohn Kendrew
John Kendrew determined the structure of the myoglobin protein in 1957. He shared the 1962 Nobel Prize in Chemistry with Max Perutz, who determined the structure of hemoglobin.
Leroy HoodLeroy Hood
Leroy Hood, MD, PhD, developed the automated genetic sequencer in 1986 and was a strong proponent of the Human Genome Project. He is the founder and president of the Institute for Systems Biology in Seattle, Washington.
Max PerutzMax Perutz
Max Perutz determined the structure of the hemoglobin protein in 1959. The work took him 22 years. He shared the 1962 Nobel Prize in Chemistry with John Kendrew, who discovered the structure of myoglobin.
Protein crystalProtein crystal
To determine the structure of a protein, scientists use X-ray crystallography, a process in which they crystallize the protein and use an X ray to determine defraction patterns.
Protein interaction Protein interaction
A network of protein-protein interactions in a yeast cell
Protein structureProtein structure
Primary Structure: The specific sequence of amino acids in a polypeptide chain. Secondary Structure: The folding of the polypeptide chain into specific shapes, such as the alpha helix and beta pleated sheet. Other regions of secondary structure may include turns and random coils. Tertiary Structure: The unique three-dimensional shape that is the result of chemical interactions between amino acids that fold the regions of secondary structure. Quaternary Structure: The specific interaction of two or more polypeptide subunits.
  Home  |  Channel  |  Catalog  |  About Us  |  Search  |  Contact Us  
  © Annenberg Foundation 2013. All rights reserved. Privacy Policy