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Unit 6: HIV and Aids
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Edward A. Berger, PhD
Chief, Molecular Structure Section, NIAID, NIH
Berger is chief of the Molecular Structure Section in the laboratory of viral diseases in NIAID and NIH. Berger's lab identified the first HIV co-receptor, a molecule that Dr. Berger and his colleagues dubbed "fusin." They showed that fusin must be present on the surface of CD4+ T cells in order for HIV to enter and infect these cells. Soon thereafter, Berger's group and others showed that other HIV strains use different co-receptors to gain entry into target cells. Many of these molecules ordinarily function as receptors for chemokines, proteins that help orchestrate immune responses.

Laurie Garret
Journalist, Newsday
Garret is the author of the books The Coming Plague: Newly Emerging Diseases in a World Out of Balance and Betrayal of Trust: The Collapse of Global Public Health. She is also a medical and science writer for Newsday, in New York City. For her work, she has been awarded The Peabody, The Polk, and The Pulitzer Prize.

Jay Levy, MD
Professor of Medicine; Research Associate, Cancer Research Institute
Levy is a professor in the Department of Medicine and research associate at the Cancer Research Institute at UCSF. His research focuses on biologic, immunologic, and molecular studies of the AIDS virus, emphasizing viral and immunologic features of HIV pathogenesis and long-term survival. Dr. Levy's group was one of the first to identify HIV, originally calling it the AIDS-associated retrovirus.

Erik von Muller
Von Muller was infected with the HIV virus in the early 1980s and is what is known as a long-term non-progressor: he has not developed AIDS. He is a participant in a study conducted by Dr. Jay Levy on long-term non-progressors.

David Weiner, PhD
Associate Professor of Pathology and Laboratory Medicine
Weiner is an associate professor in the Department of Pathology & Laboratory Medicine and the Department of Otorhinolaryngology of the University of Pennsylvania School of Medicine. He is also a member of the Center for AIDS Research at the University of Pennsylvania. His research can be divided into the exploration of novel methods for the generation of antiviral immune responses, and dissecting the molecular virology of HIV-1. Weiner's lab was the first to identify an HIV gene that is associated with viral latency and silent infection. This should provide important clues about how silent infections are established in HIV-infected people, and how these silent infections later give way to AIDS.


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