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Unit 1: Genomics
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Book
Krane, D. E., and Raymer, M. L. 2003. Fundamental concepts of
bioinformatics
. San Francisco: Benjamin/Cummings.


Articles
Adams, A. 2002. Prospecting for gold in genome gulch. The Scientist
16:36–38. Modern-day bioprospectors combine association, functional, and gene expression data to stake their claims in the rich veins of human DNA.

Ezzell, C. 2003. Scientific American: Beyond the human genome.
An e-book that describes the challenges remaining now that we have sequenced the human genome.


Friend, S. H., and R. B. Stoughton. 2002. The magic of microarrays.
Scientific American 286:44–53. DNA microarrays could hasten the day when custom-tailored treatment plans replace a one-size-fits-all approach to medicine.

Howard, K. 2000. The bioinformatics gold rush. Scientific American
283:58–63. A $300-million industry has emerged around turning raw genome data into knowledge for making new drugs.

Kling, J. 2002. Speed-reading the genome. The Scientist 16:49.
With a novel approach, US Genomics shoots for viable, real-time genomic sequencing.

Klotzko, A. J. 2000. SNPs of disease. Scientific American 282:28.
The U.K. plans a national genomic database to study late-onset sickness.

Pistoi, S. 2002. Facing your genetic destiny, Part II. Scientific American
Explore Online. Finding treatments that match individual gene profiles is the next frontier in drug research and the objective of a newscience called pharmacogenomics.

Stix, G. 2002. Legal circumvention. Scientific American 287:36.
Molecular switches provide a route around existing gene patents.

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