Case Study: Designing Cancer Drugs: Development of Gleevec

CML
Chronic myelogenous leukemia (CML) is an unusual cancer because a single mutation is initially responsible and we know the function of the mutated gene. The mutant gene, called Bcr-Abl, encodes a kinase in a signal transduction pathway.

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Bcr-Abl mutation.

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Graphic: Signal Transduction Pathway
Drug Development Timeline