1440s
Portuguese begin to trade for enslaved Africans
1492
Christopher Columbus lands on San
Salvador and encounters the Tainos
1493
Christopher Columbus introduces pigs to the Greater Antilles
1513
The Ais and Calusas peoples harass Ponce de León’s expedition across Florida
1518
Smallpox virus erupts on Hispaniola
1521
Juan Garrido participates in siege of Tenochtitlan
1528–1536
Esteban and his companions travel across Southwest, where they are first enslaved by the Karankawa, but later assisted by the Pima and the Avavre
1534
The Micmac Indians encounter Jaques Cartier on Gaspé Peninsula in eastern Quebec
1539–1543
Hernando De Soto expedition wages war on Timucua
1578
Miwok Indians encounter Sir Francis Drake on California coast
1634
Jean Nicolet travels with Huron through Straits of Mackinac
1665
Father Jean Claude Allouez founds trading post on Chequamegon Bay and trades with Souix and Illinois Indians
1673
Jacques Marquette learns of the Mississippi River from the Native Americans in Illinois
1730s
Smallpox epidemic decimates Souix
1741
Bering's expedition and Aleuts meet in what will become Alaska
1778
Hawai’ian islanders welcome James Cook’s expedition and establish trade
1805
Narbona invades Navajo territory
in Navajo territory
1805
Watkuweis and Nez Perce aid
Lewis and Clark expedition
1589
Spanish establish New Mexico colony
1607
English establish Jamestown Colony in Virginia